Version 5.4
Homo sapiens Protein: PSD4
Summary
InnateDB Protein IDBP-66890.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PSD4
Protein Name pleckstrin and Sec7 domain containing 4
Synonyms EFA6B; TIC;
Species Homo sapiens
Ensembl Protein ENSP00000245796
InnateDB Gene IDBG-66888 (PSD4)
Protein Structure
UniProt Annotation
Function Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5- bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269PubMed:12082148, ECO:0000269PubMed:21458045}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:12082148}. Note=Accumulates in dynamic actin-rich membrane ruffles and microvilli-like structures. Recruited to membranes via phosphatidylinositol phosphate-binding.
Disease Associations
Tissue Specificity Widely expressed. Highest levels of expression are found in placenta, pancreas, spleen, thymus and peripheral blood. {ECO:0000269PubMed:12082148}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005086 ARF guanyl-nucleotide exchange factor activity
GO:0005543 phospholipid binding
Biological Process
GO:0030182 neuron differentiation
GO:0032012 regulation of ARF protein signal transduction
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030054 cell junction
Protein Structure and Domains
PDB ID
InterPro IPR000904 Sec7 domain
IPR001605 Pleckstrin homology domain, spectrin-type
IPR001849 Pleckstrin homology domain
PFAM PF01369
PF00169
PRINTS PR00683
PIRSF
SMART SM00222
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NDX1
PhosphoSite PhosphoSite-Q8NDX1
TrEMBL B3KN27
UniProt Splice Variant
Entrez Gene 23550
UniGene Hs.716048
RefSeq NP_036587
HUGO HGNC:19096
OMIM 614442
CCDS CCDS33276
HPRD 15191
IMGT
EMBL AC016683 AJ459781 AK023421 AK290045 BC035307 BC073151 CH471217 DQ452296 U63127
GenPept AAD00107 AAH35307 AAH73151 AAX88879 ABD96831 BAF82734 BAG51189 CAD30842 EAW73626 EAW73627 EAW73628

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca