InnateDB Protein
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IDBP-67005.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TTYH2
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Protein Name
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tweety homolog 2 (Drosophila)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000269346
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InnateDB Gene
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IDBG-67003 (TTYH2)
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Protein Structure
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Function |
Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. May be involved in cell proliferation and cell aggregation. {ECO:0000269PubMed:15010458}.
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Subcellular Localization |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed at higher level in brain and testis and at lower levels in heart, ovary, spleen and peripheral blood leukocytes. Up-regulated in 13 of 16 renal cell carcinoma samples examined. Up-regulated in colon carcinoma. {ECO:0000269PubMed:11597145, ECO:0000269PubMed:17569141}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006990
Tweety
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PFAM |
PF04906
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BSA4
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PhosphoSite |
PhosphoSite-Q9BSA4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
94015
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UniGene |
Hs.27935
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RefSeq |
NP_116035
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HUGO |
HGNC:13877
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OMIM |
608855
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CCDS |
CCDS32717
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HPRD |
16394
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IMGT |
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EMBL |
AC100786
AF319952
AK091085
AK126955
BC005168
BC107492
BC107602
BX647912
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GenPept |
AAH05168
AAI07493
AAI07603
AAL16784
BAC03579
BAG54409
CAH10576
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