InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DEFB4A

Summary

InnateDB Protein

IDBP-6713.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DEFB4A

Protein Name

defensin, beta 4A

Synonyms

BD-2; DEFB-2; DEFB102; DEFB2; DEFB4; HBD-2; SAP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000303532

InnateDB Gene

IDBG-6711 (DEFB4A)

Protein Structure

UniProt Annotation

Function

Has antibacterial activity. {ECO:0000305}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed in the skin and respiratory tract.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0006935	chemotaxis
GO:0006952	defense response
GO:0006955	immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0042742	defense response to bacterium
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005576	extracellular region
GO:0005796	Golgi lumen

Protein Structure and Domains

PDB ID

InterPro

IPR001855 Beta defensin type
IPR006080 Beta defensin/Neutrophil defensin

PFAM

PF00711

PRINTS

PIRSF

SMART

SM00048

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O15263

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

1673

UniGene

RefSeq

NP_004933

HUGO

HGNC:2767

OMIM

602215

CCDS

CCDS5971

HPRD

03739

IMGT

EMBL

AF040153 AF071216 AJ000152 BC069285 BC093983 BC093985 Z71389

GenPept

AAC33549 AAC69554 AAH69285 AAH93983 AAH93985 CAA95992 CAB65126