InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ABCC5

Summary

InnateDB Protein

IDBP-67161.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABCC5

Protein Name

ATP-binding cassette, sub-family C (CFTR/MRP), member 5

Synonyms

ABC33; EST277145; MOAT-C; MOATC; MRP5; pABC11; SMRP;

Species

Homo sapiens

Ensembl Protein

ENSP00000333926

InnateDB Gene

IDBG-67159 (ABCC5)

Protein Structure

UniProt Annotation

Function

Acts as a multispecific organic anion pump which can transport nucleotide analogs. {ECO:0000269PubMed:10840050}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

All isoforms are equally expressed in retina. {ECO:0000269PubMed:17521428}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0008514	organic anion transmembrane transporter activity
GO:0016887	ATPase activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0015711	organic anion transport
GO:0030203	glycosaminoglycan metabolic process
GO:0030212	hyaluronan metabolic process
GO:0030213	hyaluronan biosynthetic process
GO:0044281	small molecule metabolic process
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001140 ABC transporter, transmembrane domain
IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR011527 ABC transporter type 1, transmembrane domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00664
PF13748
PF00005

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O15440