InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTPRM

Summary

InnateDB Protein

IDBP-672.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPRM

Protein Name

protein tyrosine phosphatase, receptor type, M

Synonyms

hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU;

Species

Homo sapiens

Ensembl Protein

ENSP00000331418

InnateDB Gene

IDBG-670 (PTPRM)

Protein Structure

UniProt Annotation

Function

Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control. {ECO:0000269PubMed:16456543}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity
GO:0042802	identical protein binding
GO:0045296	cadherin binding

Biological Process

GO:0001937	negative regulation of endothelial cell proliferation
GO:0006470	protein dephosphorylation
GO:0007156	homophilic cell adhesion
GO:0007165	signal transduction
GO:0010596	negative regulation of endothelial cell migration
GO:0010842	retina layer formation
GO:0016311	dephosphorylation
GO:0016525	negative regulation of angiogenesis
GO:0031175	neuron projection development
GO:0031290	retinal ganglion cell axon guidance
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0042493	response to drug

Cellular Component

GO:0005737	cytoplasm
GO:0005887	integral component of plasma membrane
GO:0005911	cell-cell junction
GO:0005913	cell-cell adherens junction
GO:0016020	membrane
GO:0030027	lamellipodium
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR000998 MAM domain
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR013151 Immunoglobulin
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00629
PF00041
PF01108
PF00047

PRINTS

PR00700
PR00020

PIRSF

SMART

SM00194
SM00137
SM00404
SM00409
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt