Version 5.4
Homo sapiens Protein: PPP1R14D
Summary
InnateDB Protein IDBP-6730.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP1R14D
Protein Name protein phosphatase 1, regulatory (inhibitor) subunit 14D
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000299174
InnateDB Gene IDBG-6728 (PPP1R14D)
Protein Structure
UniProt Annotation
Function Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. {ECO:0000269PubMed:12974676}.
Subcellular Localization Cytoplasm {ECO:0000305}.
Disease Associations
Tissue Specificity Detected in colon, intestine, kidney and brain cortex. {ECO:0000269PubMed:12974676}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004864 protein phosphatase inhibitor activity
Biological Process
GO:0042325 regulation of phosphorylation
GO:0043086 negative regulation of catalytic activity
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR008025 PKC-activated phosphatase-1 inhibitor
PFAM PF05361
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NXH3
PhosphoSite PhosphoSite-Q9NXH3
TrEMBL Q4V755
UniProt Splice Variant
Entrez Gene 54866
UniGene Hs.192927
RefSeq NP_060196
HUGO HGNC:14953
OMIM 613256
CCDS CCDS10066
HPRD 17891
IMGT
EMBL AK000258 AY050671 BC096716 BC098124 BC098150 BC098341
GenPept AAH96716 AAH98124 AAH98150 AAH98341 AAL25829 BAA91037

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca