InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GGA1

Summary

InnateDB Protein

IDBP-6733.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GGA1

Protein Name

golgi-associated, gamma adaptin ear containing, ARF binding protein 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000341344

InnateDB Gene

IDBG-6731 (GGA1)

Protein Structure

UniProt Annotation

Function

Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif. {ECO:0000269PubMed:11301005}.

Subcellular Localization

Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Ubiquitously expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 77 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	77 [view]
Protein-Protein	77 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0006886	intracellular protein transport
GO:0016192	vesicle-mediated transport
GO:0045732	positive regulation of protein catabolic process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005794	Golgi apparatus
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0030131	clathrin adaptor complex
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR002014 VHS
IPR004152 GAT
IPR008152 Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
IPR008153 Clathrin adaptor, gamma-adaptin, appendage
IPR008942 ENTH/VHS
IPR013041 Coatomer/clathrin adaptor appendage, Ig-like subdomain
IPR018205 VHS subgroup

PFAM

PF00790
PF03127
PF02883

PRINTS

PIRSF

SMART

SM00809
SM00288

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UJY5