InnateDB Protein
|
IDBP-67413.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
NUDT11
|
Protein Name
|
nudix (nucleoside diphosphate linked moiety X)-type motif 11
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000365160
|
InnateDB Gene
|
IDBG-67411 (NUDT11)
|
Protein Structure
|
|
Function |
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.
|
Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:12121577}.
|
Disease Associations |
|
Tissue Specificity |
Mainly expressed in testis and, at lower level in brain. According to PubMed:12121577, it is also expressed in pancreas and weakly expressed in thymus, prostate, ovary, lung, small intestine and heart. {ECO:0000269PubMed:12105228, ECO:0000269PubMed:12121577}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
1
[view]
|
Protein-DNA |
1
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0008486
|
diphosphoinositol-polyphosphate diphosphatase activity
|
GO:0016787
|
hydrolase activity
|
GO:0046872
|
metal ion binding
|
GO:0052840
|
inositol diphosphate tetrakisphosphate diphosphatase activity
|
GO:0052843
|
inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity
|
GO:0052844
|
inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity
|
GO:0052845
|
inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity
|
GO:0052846
|
inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity
|
GO:0052847
|
inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
|
GO:0052848
|
inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000086
NUDIX hydrolase domain
IPR015797
NUDIX hydrolase domain-like
|
PFAM |
PF00293
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q96G61
|
PhosphoSite |
PhosphoSite-Q96G61
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
55190
|
UniGene |
Hs.200016
|
RefSeq |
NP_060629
|
HUGO |
HGNC:18011
|
OMIM |
300528
|
CCDS |
CCDS43952
|
HPRD |
06667
|
IMGT |
|
EMBL |
AK001490
AL158055
BC009942
|
GenPept |
AAH09942
BAA91720
CAI40294
|
|
|