InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DDX18

Summary

InnateDB Protein

IDBP-67468.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDX18

Protein Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 18

Synonyms

MrDb;

Species

Homo sapiens

Ensembl Protein

ENSP00000263239

InnateDB Gene

IDBG-67466 (DDX18)

Protein Structure

UniProt Annotation

Function

Probable RNA-dependent helicase.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:16963496}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	23 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004004	ATP-dependent RNA helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006200

ATP catabolic process

Cellular Component

GO:0005730	nucleolus
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR011545 DEAD/DEAH box helicase domain
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00270

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NVP1