InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHORDC1

Summary

InnateDB Protein

IDBP-67751.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHORDC1

Protein Name

cysteine and histidine-rich domain (CHORD) containing 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000319255

InnateDB Gene

IDBG-67749 (CHORDC1)

Protein Structure

UniProt Annotation

Function

Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis. {ECO:0000269PubMed:20230755}.

Subcellular Localization

Disease Associations

Tissue Specificity

Underexpressed in many breast and lung cancers. {ECO:0000269PubMed:20230755}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0051879	Hsp90 protein binding

Biological Process

GO:0006950	response to stress
GO:0010824	regulation of centrosome duplication
GO:0061077	chaperone-mediated protein folding
GO:1900034	regulation of cellular response to heat
GO:2000299	negative regulation of Rho-dependent protein serine/threonine kinase activity