Version 5.4
Homo sapiens Protein: EN1
Summary
InnateDB Protein IDBP-67829.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EN1
Protein Name engrailed homeobox 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000295206
InnateDB Gene IDBG-67827 (EN1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001501 skeletal system development
GO:0009653 anatomical structure morphogenesis
GO:0009953 dorsal/ventral pattern formation
GO:0009954 proximal/distal pattern formation
GO:0010468 regulation of gene expression
GO:0030182 neuron differentiation
GO:0030326 embryonic limb morphogenesis
GO:0030901 midbrain development
GO:0030902 hindbrain development
GO:0030917 midbrain-hindbrain boundary development
GO:0035115 embryonic forelimb morphogenesis
GO:0035264 multicellular organism growth
GO:0042220 response to cocaine
GO:0043473 pigmentation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048666 neuron development
GO:0060173 limb development
Cellular Component
GO:0005634 nucleus
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000104 Antifreeze protein, type I
IPR000747 Homeodomain engrailed
IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR019549 Homeobox engrailed, C-terminal
IPR020467 Potassium channel, voltage dependent, Kv1.4
IPR020479 Homeodomain, metazoa
PFAM PF00046
PF10525
PRINTS PR00308
PR00026
PR01511
PR00024
PIRSF
SMART SM00389
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q05925
PhosphoSite PhosphoSite-Q05925
TrEMBL
UniProt Splice Variant
Entrez Gene 2019
UniGene Hs.604307
RefSeq NP_001417
HUGO HGNC:3342
OMIM 131290
CCDS CCDS2123
HPRD 08835
IMGT
EMBL AC012665 CH471103 L12698 L12699
GenPept AAA53502 AAX88967 EAW95206

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca