Version 5.4
Homo sapiens Protein: MARCO
Summary
InnateDB Protein IDBP-67849.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MARCO
Protein Name macrophage receptor with collagenous structure
Synonyms SCARA2;
Species Homo sapiens
Ensembl Protein ENSP00000318916
InnateDB Gene IDBG-67847 (MARCO)
Protein Structure
UniProt Annotation
Function Pattern recognition receptor (PRR). Binds Gram-positive and Gram-negative bacteria.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005044 scavenger receptor activity
GO:0008329 signaling pattern recognition receptor activity
Biological Process
GO:0002221 pattern recognition receptor signaling pathway
GO:0006897 endocytosis
GO:0006898 receptor-mediated endocytosis
GO:0007166 cell surface receptor signaling pathway
GO:0043277 apoptotic cell clearance
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005581 collagen trimer
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0030666 endocytic vesicle membrane
Protein Structure and Domains
PDB ID
InterPro IPR001190 SRCR domain
IPR008160 Collagen triple helix repeat
IPR017448 SRCR-like domain
PFAM PF00530
PF01391
PRINTS PR00258
PIRSF
SMART SM00202
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UEW3
PhosphoSite PhosphoSite-Q9UEW3
TrEMBL Q4ZG40
UniProt Splice Variant
Entrez Gene 8685
UniGene Hs.67726
RefSeq NP_006761
HUGO HGNC:6895
OMIM 604870
CCDS CCDS2124
HPRD 05337
IMGT
EMBL AC013457 AF035819 AF128172 AF128173 AF128174 AF128175 AF128176 AF128177 AF128178 AF128179 AF128180 AF128181 AF128182 AF128183 AF128184 AF128185 AF128186 AK297030 AK301407 AK313139 BC016004 CH471103
GenPept AAC08800 AAD41064 AAH16004 AAX88875 BAG35958 BAG59558 BAG62941 EAW95207

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca