InnateDB Protein
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IDBP-67885.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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EPC1
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Protein Name
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enhancer of polycomb homolog 1 (Drosophila)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000263062
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InnateDB Gene
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IDBG-67877 (EPC1)
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Protein Structure
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Function |
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. {ECO:0000269PubMed:14966270}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:10976108}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
23
[view]
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Protein-Protein |
23
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
Accession |
GO Term |
GO:0004402
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histone acetyltransferase activity
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006325
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chromatin organization
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GO:0006351
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transcription, DNA-templated
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GO:0040008
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regulation of growth
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GO:0043967
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histone H4 acetylation
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GO:0043968
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histone H2A acetylation
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GO:0045814
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negative regulation of gene expression, epigenetic
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GO:0045892
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negative regulation of transcription, DNA-templated
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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Cellular Component |
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PDB ID |
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InterPro |
IPR009607
Enhancer of polycomb, C-terminal
IPR019542
Enhancer of polycomb-like, N-terminal
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PFAM |
PF06752
PF10513
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9H2F5
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PhosphoSite |
PhosphoSite-Q9H2F5
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TrEMBL |
Q68DJ2
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UniProt Splice Variant |
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Entrez Gene |
80314
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UniGene |
Hs.743354
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RefSeq |
NP_079485
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HUGO |
HGNC:19876
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OMIM |
610999
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CCDS |
CCDS7172
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HPRD |
09941
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IMGT |
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EMBL |
AF277374
AF286905
AK024329
AK092304
AK299676
AL158834
AL391839
BC036529
CH471072
CR749375
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GenPept |
AAG41402
AAH36529
AAK60501
BAB14888
BAC03857
BAG61585
CAH18228
CAH70453
CAH70454
CAH70455
CAH70821
CAH70822
CAH70823
EAW85972
EAW85973
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