InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EIF2S2

Summary

InnateDB Protein

IDBP-67891.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF2S2

Protein Name

eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa

Synonyms

eIF-2-beta; EIF2; EIF2B; EIF2beta; PPP1R67;

Species

Homo sapiens

Ensembl Protein

ENSP00000364119

InnateDB Gene

IDBG-67889 (EIF2S2)

Protein Structure

UniProt Annotation

Function

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	38 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003743	translation initiation factor activity
GO:0005515	protein binding
GO:0008135	translation factor activity, nucleic acid binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0001701	in utero embryonic development
GO:0002176	male germ cell proliferation
GO:0006412	translation
GO:0006413	translational initiation
GO:0008584	male gonad development
GO:0010467	gene expression
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005829	cytosol
GO:0005850	eukaryotic translation initiation factor 2 complex

Protein Structure and Domains

PDB ID

InterPro

IPR002735 Translation initiation factor IF2/IF5
IPR016189 Translation initiation factor IF2/IF5, N-terminal
IPR016190 Translation initiation factor IF2/IF5, zinc-binding

PFAM

PF01873

PRINTS

PIRSF

SMART

SM00653

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P20042