InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ICT1

Summary

InnateDB Protein

IDBP-67897.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ICT1

Protein Name

immature colon carcinoma transcript 1

Synonyms

DS-1; DS1; MRP-L58;

Species

Homo sapiens

Ensembl Protein

ENSP00000301585

InnateDB Gene

IDBG-67895 (ICT1)

Protein Structure

UniProt Annotation

Function

Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes. {ECO:0000269PubMed:20186120}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:20186120, ECO:0000269PubMed:23908630}.

Disease Associations

Tissue Specificity

Down-regulated during the in vitro differentiation of HT29-D4 colon carcinoma cells. {ECO:0000269PubMed:8575443}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 254 experimentally validated interaction(s) in this database.

Experimentally validated
Total	254 [view]
Protein-Protein	253 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003747	translation release factor activity
GO:0004045	aminoacyl-tRNA hydrolase activity
GO:0016150	translation release factor activity, codon nonspecific