Version 5.4
Homo sapiens Protein: CACNG8
Summary
InnateDB Protein IDBP-67911.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CACNG8
Protein Name calcium channel, voltage-dependent, gamma subunit 8
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000270458
InnateDB Gene IDBG-67909 (CACNG8)
Protein Structure
UniProt Annotation
Function Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. {ECO:0000269PubMed:20805473, ECO:0000269PubMed:21172611}.
Subcellular Localization Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005245 voltage-gated calcium channel activity
Biological Process
GO:0006816 calcium ion transport
GO:0007268 synaptic transmission
GO:0070588 calcium ion transmembrane transport
GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
Cellular Component
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0014069 postsynaptic density
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030666 endocytic vesicle membrane
GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID
InterPro IPR004031 PMP-22/EMP/MP20/Claudin superfamily
IPR006187 Claudin
IPR008368 Voltage-dependent calcium channel, gamma subunit
IPR008372 Voltage-dependent calcium channel, gamma-8 subunit
PFAM PF00822
PF13903
PRINTS PR01077
PR01792
PR01796
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WXS5
PhosphoSite PhosphoSite-Q8WXS5
TrEMBL
UniProt Splice Variant
Entrez Gene 59283
UniGene Hs.631595
RefSeq NP_114101
HUGO HGNC:13628
OMIM 606900
CCDS CCDS33104
HPRD 06063
IMGT
EMBL AC008440 AF234892 AF288388 AF361354
GenPept AAK15019 AAK20031 AAL50049

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca