InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VSTM1

Summary

InnateDB Protein

IDBP-67967.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VSTM1

Protein Name

V-set and transmembrane domain containing 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000343366

InnateDB Gene

IDBG-67965 (VSTM1)

Protein Structure

UniProt Annotation

Function

Isoform 2: Behaves as a cytokine, promoting IL17A secretion by CD4+ T-cells, and differentiation and activation of IL17 producing helper T-cells (TH17).Isoform 1: Inhibitory immune receptor involved in the regulation of phagocytes.

Subcellular Localization

Isoform 1: Membrane {ECO:0000305}; Single- pass membrane protein {ECO:0000305}.Isoform 2: Secreted {ECO:0000269PubMed:22960280}.

Disease Associations

Tissue Specificity

Expressed on myeloid (neutrophils, eosinophils and monocytes) but not on lymphoid cells. {ECO:0000269PubMed:20375307}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005515	protein binding

Biological Process

GO:0002376

immune system process

Cellular Component

GO:0005615	extracellular space
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain

PFAM

PRINTS

PIRSF

SMART

SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6UX27

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

284415

UniGene

Hs.444431

RefSeq

NP_940883

HUGO

HGNC:29455

OMIM

CCDS

CCDS12872

HPRD

15615

IMGT

EMBL

AC012314 AY358542 BC100942 BC100943 DQ479397 FJ584316 FJ584317 FJ584318 FN398145

GenPept

AAI00943 AAI00944 AAQ88906 ABF19807 ACU00108 ACU00109 ACU00110 CAZ61324