InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: GABRP

Summary

InnateDB Protein

IDBP-679768.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GABRP

Protein Name

Gamma-aminobutyric acid receptor subunit pi

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000003604

InnateDB Gene

IDBG-628414 (GABRP)

Protein Structure

UniProt Annotation

Function

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone (By similarity). {ECO:0000250}.

Subcellular Localization

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004890	GABA-A receptor activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005254	chloride channel activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006821	chloride transport
GO:0007165	signal transduction
GO:0034220	ion transmembrane transport
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0034707	chloride channel complex
GO:0045202	synapse
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

InterPro

IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding
IPR008100 Gamma-aminobutyric-acid A receptor pi subunit

PFAM

PF02932
PF02931

PRINTS

PR00253
PR00252
PR01724

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5EA06