Version 5.4
Bos taurus Protein: NKX2-5
Summary
InnateDB Protein IDBP-679870.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NKX2-5
Protein Name homeobox protein Nkx-2.5
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000027402
InnateDB Gene IDBG-628505 (NKX2-5)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0001190 RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0010736 serum response element binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001570 vasculogenesis
GO:0001947 heart looping
GO:0003007 heart morphogenesis
GO:0003148 outflow tract septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003161 cardiac conduction system development
GO:0003162 atrioventricular node development
GO:0003166 bundle of His development
GO:0003168 Purkinje myocyte differentiation
GO:0003208 cardiac ventricle morphogenesis
GO:0003211 cardiac ventricle formation
GO:0003221 right ventricular cardiac muscle tissue morphogenesis
GO:0003222 ventricular trabecula myocardium morphogenesis
GO:0003278 apoptotic process involved in heart morphogenesis
GO:0003285 septum secundum development
GO:0003342 proepicardium development
GO:0003350 pulmonary myocardium development
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007507 heart development
GO:0007512 adult heart development
GO:0008284 positive regulation of cell proliferation
GO:0010628 positive regulation of gene expression
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0010735 positive regulation of transcription via serum response element binding
GO:0010765 positive regulation of sodium ion transport
GO:0010832 negative regulation of myotube differentiation
GO:0030097 hemopoiesis
GO:0030154 cell differentiation
GO:0030509 BMP signaling pathway
GO:0030878 thyroid gland development
GO:0035050 embryonic heart tube development
GO:0043066 negative regulation of apoptotic process
GO:0045214 sarcomere organization
GO:0045666 positive regulation of neuron differentiation
GO:0045823 positive regulation of heart contraction
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048536 spleen development
GO:0048738 cardiac muscle tissue development
GO:0051891 positive regulation of cardioblast differentiation
GO:0055005 ventricular cardiac myofibril assembly
GO:0055007 cardiac muscle cell differentiation
GO:0055008 cardiac muscle tissue morphogenesis
GO:0055117 regulation of cardiac muscle contraction
GO:0060037 pharyngeal system development
GO:0060038 cardiac muscle cell proliferation
GO:0060043 regulation of cardiac muscle cell proliferation
GO:0060047 heart contraction
GO:0060048 cardiac muscle contraction
GO:0060070 canonical Wnt signaling pathway
GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter
GO:0060347 heart trabecula formation
GO:0060412 ventricular septum morphogenesis
GO:0060413 atrial septum morphogenesis
GO:0060928 atrioventricular node cell development
GO:0060929 atrioventricular node cell fate commitment
GO:0060971 embryonic heart tube left/right pattern formation
GO:0072358 cardiovascular system development
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1901387 positive regulation of voltage-gated calcium channel activity
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR020479 Homeodomain, metazoa
PFAM PF00046
PRINTS PR00024
PIRSF
SMART SM00389
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q29RN9
UniProt Splice Variant
Entrez Gene 538870
UniGene Bt.54814
RefSeq NP_001039908
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC114089 DAAA02049906
GenPept AAI14090

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca