Version 5.4
Bos taurus Protein: MSX2
Summary
InnateDB Protein IDBP-679881.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MSX2
Protein Name Homeobox protein MSX-2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000018417
InnateDB Gene IDBG-628518 (MSX2)
Protein Structure
UniProt Annotation
Function Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000989 transcription factor binding transcription factor activity
GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003712 transcription cofactor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001503 ossification
GO:0001649 osteoblast differentiation
GO:0002063 chondrocyte development
GO:0002076 osteoblast development
GO:0003148 outflow tract septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003416 endochondral bone growth
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0008285 negative regulation of cell proliferation
GO:0009952 anterior/posterior pattern specification
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030326 embryonic limb morphogenesis
GO:0030509 BMP signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0032792 negative regulation of CREB transcription factor activity
GO:0035115 embryonic forelimb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0035313 wound healing, spreading of epidermal cells
GO:0035880 embryonic nail plate morphogenesis
GO:0042060 wound healing
GO:0042476 odontogenesis
GO:0042640 anagen
GO:0042733 embryonic digit morphogenesis
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0045599 negative regulation of fat cell differentiation
GO:0045617 negative regulation of keratinocyte differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048863 stem cell differentiation
GO:0051216 cartilage development
GO:0051795 positive regulation of catagen
GO:0060346 bone trabecula formation
GO:0060349 bone morphogenesis
GO:0060364 frontal suture morphogenesis
GO:0060444 branching involved in mammary gland duct morphogenesis
GO:0061180 mammary gland epithelium development
GO:0061312 BMP signaling pathway involved in heart development
GO:0070166 enamel mineralization
GO:0071363 cellular response to growth factor stimulus
GO:0071392 cellular response to estradiol stimulus
GO:0090427 activation of meiosis
GO:2000678 negative regulation of transcription regulatory region DNA binding
GO:2001055 positive regulation of mesenchymal cell apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Protein Structure and Domains
PDB ID
InterPro IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR020479 Homeodomain, metazoa
PFAM PF00046
PRINTS PR00024
PIRSF
SMART SM00389
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q0P5C3
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 540230
UniGene Bt.102117
RefSeq NP_001073082
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC120248
GenPept AAI20249

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca