InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CASP3

Summary

InnateDB Protein

IDBP-679884.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CASP3

Protein Name

caspase-3 precursor

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000021099

InnateDB Gene

IDBG-628521 (CASP3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 103 interaction(s) predicted by orthology.

Predicted by orthology
Total	103 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004190	aspartic-type endopeptidase activity
GO:0004197	cysteine-type endopeptidase activity
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity
GO:0016787	hydrolase activity
GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process
GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis

Biological Process

GO:0001782	B cell homeostasis
GO:0001836	release of cytochrome c from mitochondria
GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0006974	cellular response to DNA damage stimulus
GO:0007507	heart development
GO:0007605	sensory perception of sound
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009411	response to UV
GO:0009611	response to wounding
GO:0016485	protein processing
GO:0030182	neuron differentiation
GO:0030216	keratinocyte differentiation
GO:0030218	erythrocyte differentiation
GO:0030889	negative regulation of B cell proliferation
GO:0034349	glial cell apoptotic process
GO:0043029	T cell homeostasis
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043525	positive regulation of neuron apoptotic process
GO:0045165	cell fate commitment
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045786	negative regulation of cell cycle
GO:0046007	negative regulation of activated T cell proliferation
GO:0051402	neuron apoptotic process
GO:0071310	cellular response to organic substance
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:0097194	execution phase of apoptosis
GO:1902510	regulation of apoptotic DNA fragmentation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR001309 Peptidase C14, ICE, catalytic subunit p20
IPR002138 Peptidase C14, caspase non-catalytic subunit p10
IPR011600 Peptidase C14, caspase domain
IPR015917 Peptidase C14A, caspase precursor p45, core

PFAM

PF00656

PRINTS

PR00376

PIRSF

SMART

SM00115

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt