InnateDB Protein
|
IDBP-6799.4
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
POLR3K
|
Protein Name
|
polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000293860
|
InnateDB Gene
|
IDBG-6797 (POLR3K)
|
Protein Structure
|
|
Function |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Nucleus {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
7
[view]
|
Protein-Protein |
1
[view]
|
Protein-DNA |
6
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR001222
Zinc finger, TFIIS-type
IPR001529
DNA-directed RNA polymerase, M/15kDa subunit
|
PFAM |
PF01096
PF02150
|
PRINTS |
|
PIRSF |
|
SMART |
SM00440
SM00661
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9Y2Y1
|
PhosphoSite |
PhosphoSite-Q9Y2Y1
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
51728
|
UniGene |
|
RefSeq |
NP_057394
|
HUGO |
HGNC:14121
|
OMIM |
606007
|
CCDS |
CCDS10395
|
HPRD |
16187
|
IMGT |
|
EMBL |
AE006462
AF051316
AF060223
AF126531
BC011932
DQ431198
Z69719
|
GenPept |
AAD31424
AAF18268
AAG43123
AAH11932
AAK61210
ABD95903
CAI95605
|
|
|