Version 5.4
Bos taurus Protein: TAF9
Summary
InnateDB Protein IDBP-680033.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TAF9
Protein Name Transcription initiation factor TFIID subunit 9
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000035237
InnateDB Gene IDBG-628662 (TAF9)
Protein Structure
UniProt Annotation
Function Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.
Predicted by orthology
Total 71 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002039 p53 binding
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
GO:0033613 activating transcription factor binding
GO:0044212 transcription regulatory region DNA binding
GO:0046982 protein heterodimerization activity
GO:0070742 C2H2 zinc finger domain binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006352 DNA-templated transcription, initiation
GO:0006355 regulation of transcription, DNA-templated
GO:0030307 positive regulation of cell growth
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043066 negative regulation of apoptotic process
GO:0043966 histone H3 acetylation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050821 protein stabilization
GO:0060760 positive regulation of response to cytokine stimulus
GO:0070555 response to interleukin-1
Cellular Component
GO:0000125 PCAF complex
GO:0005634 nucleus
GO:0005669 transcription factor TFIID complex
GO:0030914 STAGA complex
GO:0033276 transcription factor TFTC complex
GO:0070761 pre-snoRNP complex
GO:0071339 MLL1 complex
Protein Structure and Domains
PDB ID
InterPro IPR003162 Transcription initiation factor TAFII31
IPR006565 Bromodomain transcription factor
IPR009072 Histone-fold
PFAM PF02291
PF07524
PRINTS
PIRSF
SMART SM00576
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q17QQ4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 532936
UniGene Bt.70111
RefSeq NP_001069443
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC118236
GenPept AAI18237

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca