Version 5.4
Bos taurus Protein: MSR1
Summary
InnateDB Protein IDBP-680094.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MSR1
Protein Name Macrophage scavenger receptor types I and II
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000003751
InnateDB Gene IDBG-628711 (MSR1)
Protein Structure
UniProt Annotation
Function Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL).
Subcellular Localization Membrane; Single-pass type II membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004871 signal transducer activity
GO:0005044 scavenger receptor activity
GO:0005515 protein binding
GO:0030169 low-density lipoprotein particle binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006897 endocytosis
GO:0006898 receptor-mediated endocytosis
GO:0007165 signal transduction
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0010886 positive regulation of cholesterol storage
GO:0030301 cholesterol transport
GO:0034381 plasma lipoprotein particle clearance
GO:0042953 lipoprotein transport
Cellular Component
GO:0005581 collagen trimer
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0034362 low-density lipoprotein particle
Protein Structure and Domains
PDB ID
InterPro IPR001190 SRCR domain
IPR003543 Macrophage scavenger receptor
IPR008160 Collagen triple helix repeat
IPR015988 STAT transcription factor, coiled coil
IPR017448 SRCR-like domain
PFAM PF00530
PF03523
PF01391
PRINTS PR00258
PR01408
PIRSF
SMART SM00202
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P21758
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281311
UniGene Bt.4482
RefSeq NP_001106711
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC142250 X51689 X54183
GenPept AAI42251 CAA35987 CAA38108

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca