Version 5.4
Bos taurus Protein: GCLC
Summary
InnateDB Protein IDBP-680138.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GCLC
Protein Name glutamate--cysteine ligase catalytic subunit
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000045984
InnateDB Gene IDBG-628748 (GCLC)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004357 glutamate-cysteine ligase activity
GO:0016595 glutamate binding
GO:0016874 ligase activity
GO:0043531 ADP binding
GO:0046982 protein heterodimerization activity
GO:0050662 coenzyme binding
Biological Process
GO:0006534 cysteine metabolic process
GO:0006536 glutamate metabolic process
GO:0006749 glutathione metabolic process
GO:0006750 glutathione biosynthetic process
GO:0006979 response to oxidative stress
GO:0008637 apoptotic mitochondrial changes
GO:0009408 response to heat
GO:0009410 response to xenobiotic stimulus
GO:0009725 response to hormone
GO:0019852 L-ascorbic acid metabolic process
GO:0031397 negative regulation of protein ubiquitination
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043066 negative regulation of apoptotic process
GO:0045454 cell redox homeostasis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046685 response to arsenic-containing substance
GO:0050880 regulation of blood vessel size
GO:0051900 regulation of mitochondrial depolarization
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0017109 glutamate-cysteine ligase complex
Protein Structure and Domains
PDB ID
InterPro IPR004308 Glutamate-cysteine ligase catalytic subunit
PFAM PF03074
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q32S38
UniProt Splice Variant
Entrez Gene 512468
UniGene Bt.103678
RefSeq NP_001077143
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY957499 DAAA02054875
GenPept AAY34691

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca