Bos taurus Protein: RGS7BP
Summary
InnateDB Protein IDBP-680190.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RGS7BP
Protein Name Regulator of G-protein signaling 7-binding protein
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000006815
InnateDB Gene IDBG-628813 (RGS7BP)
Protein Structure
UniProt Annotation
Function Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cypolasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Shuttling between the plasma membrane, the cytoplasm and the nucleus is regulated by palmitoylation. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0009968 negative regulation of signal transduction
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q08DH5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 613327
UniGene Bt.63144
RefSeq NP_001070398
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC123745
GenPept AAI23746