Version 5.4
Homo sapiens Protein: RHOV
Summary
InnateDB Protein IDBP-6802.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RHOV
Protein Name ras homolog gene family, member V
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000220507
InnateDB Gene IDBG-6800 (RHOV)
Protein Structure
UniProt Annotation
Function Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway. {ECO:0000250UniProtKB:Q9Z1Y0}.
Subcellular Localization Cell membrane {ECO:0000250UniProtKB:Q9Z1Y0}; Lipid-anchor {ECO:0000250UniProtKB:Q9Z1Y0}; Cytoplasmic side {ECO:0000250UniProtKB:Q9Z1Y0}. Endosome membrane {ECO:0000250UniProtKB:Q9Z1Y0}; Lipid-anchor {ECO:0000250UniProtKB:Q9Z1Y0}; Cytoplasmic side {ECO:0000250UniProtKB:Q9Z1Y0}. Note=Treatment with TNF activates endosomal but not plasma membrane RHOV. {ECO:0000250UniProtKB:Q9Z1Y0}.
Disease Associations
Tissue Specificity Highly expressed in pancreas, placenta, and fetal brain. {ECO:0000269PubMed:11956592}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0046872 metal ion binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR001806 Small GTPase superfamily
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00071
PF08477
PRINTS PR00449
PIRSF
SMART SM00174
SM00175
SM00173
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96L33
PhosphoSite PhosphoSite-Q96L33
TrEMBL A0A024R9R2
UniProt Splice Variant
Entrez Gene 171177
UniGene Hs.447901
RefSeq NP_598378
HUGO HGNC:18313
OMIM
CCDS CCDS10068
HPRD 10191
IMGT
EMBL AB079131 AY059636 BC105020 BC105022 BC112945 CH471125
GenPept AAI05021 AAI05023 AAI12946 AAL17966 BAB86363 EAW92459 EAW92460

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca