InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BT.28672

Summary

InnateDB Protein

IDBP-680205.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.28672

Protein Name

Uncharacterized protein

Synonyms

MRE11A;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000011748

InnateDB Gene

IDBG-628828 (BT.28672)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.

Predicted by orthology
Total	53 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0004518	nuclease activity
GO:0004519	endonuclease activity
GO:0004527	exonuclease activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008408	3'-5' exonuclease activity
GO:0016787	hydrolase activity
GO:0030145	manganese ion binding

Biological Process

GO:0000723	telomere maintenance
GO:0006259	DNA metabolic process
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0006289	nucleotide-excision repair
GO:0006302	double-strand break repair
GO:0006974	cellular response to DNA damage stimulus
GO:0007062	sister chromatid cohesion
GO:0007095	mitotic G2 DNA damage checkpoint
GO:0007126	meiotic nuclear division
GO:0007129	synapsis
GO:0008283	cell proliferation
GO:0031573	intra-S DNA damage checkpoint
GO:0031954	positive regulation of protein autophosphorylation
GO:0032508	DNA duplex unwinding
GO:0032876	negative regulation of DNA endoreduplication
GO:0033674	positive regulation of kinase activity
GO:0051276	chromosome organization
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0000785	chromatin
GO:0005634	nucleus
GO:0030870	Mre11 complex
GO:0035861	site of double-strand break

Protein Structure and Domains

PDB ID

InterPro

IPR003701 DNA repair protein Mre11
IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR007281 Mre11, DNA-binding
IPR029052 Metallo-dependent phosphatase-like

PFAM

PF00149
PF04152

PRINTS

PIRSF

PIRSF000882

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite