Version 5.4
Bos taurus Protein: GTF2F2
Summary
InnateDB Protein IDBP-680208.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GTF2F2
Protein Name ral transcription factor IIF subunit 2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000045836
InnateDB Gene IDBG-628833 (GTF2F2)
Protein Structure
UniProt Annotation
Function TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA- helicase activity (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.
Predicted by orthology
Total 50 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006200 ATP catabolic process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005674 transcription factor TFIIF complex
GO:0015630 microtubule cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR003196 Transcription initiation factor IIF, beta subunit
IPR011039 Transcription Factor IIF, Rap30/Rap74, interaction
IPR016640 Transcription initiation factor IIF, beta subunit, subgroup
PFAM PF02270
PRINTS
PIRSF PIRSF015849
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2T9L9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 509259
UniGene Bt.87914
RefSeq NP_001033153
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC111360
GenPept AAI11361

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca