Version 5.4
Homo sapiens Protein: TMEM37
Summary
InnateDB Protein IDBP-68021.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMEM37
Protein Name transmembrane protein 37
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000303148
InnateDB Gene IDBG-68019 (TMEM37)
Protein Structure
UniProt Annotation
Function Thought to stabilize the calcium channel in an inactivated (closed) state. Modulates calcium current when coexpressed with CACNA1G (By similarity). {ECO:0000250UniProtKB:Q9JJV3}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005244 voltage-gated ion channel activity
GO:0005262 calcium channel activity
Biological Process
GO:0034765 regulation of ion transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WXS4
PhosphoSite PhosphoSite-
TrEMBL Q86SV2
UniProt Splice Variant
Entrez Gene 140738
UniGene Hs.26216
RefSeq NP_899063
HUGO HGNC:18216
OMIM
CCDS CCDS33281
HPRD 15536
IMGT
EMBL AC013275 AF361356 BC046362
GenPept AAH46362 AAL50051 AAY14740

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca