Version 5.4
Bos taurus Protein: DUSP26
Summary
InnateDB Protein IDBP-680374.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DUSP26
Protein Name Dual specificity protein phosphatase 26
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000021830
InnateDB Gene IDBG-628989 (DUSP26)
Protein Structure
UniProt Annotation
Function Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Golgi apparatus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0002039 p53 binding
GO:0004647 phosphoserine phosphatase activity
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:0045785 positive regulation of cell adhesion
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:1902310 positive regulation of peptidyl-serine dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR020405 Atypical dual specificity phosphatase, subfamily A
IPR020417 Atypical dual specificity phosphatase
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like
PFAM PF00782
PRINTS PR01909
PR01908
PIRSF
SMART SM00195
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q17QJ3
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 533896
UniGene Bt.23521
RefSeq NP_001069472
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC118329
GenPept AAI18330

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca