InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: TRIM2

Summary

InnateDB Protein

IDBP-680462.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM2

Protein Name

tripartite motif-containing protein 2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000011609

InnateDB Gene

IDBG-629074 (TRIM2)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that mediates the ubiquitination of phosphorylated BCL2L11. Also mediates the UBE2D1-dependent ubiquitination of NEFL. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0016567	protein ubiquitination
GO:0043523	regulation of neuron apoptotic process

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000315 Zinc finger, B-box
IPR001258 NHL repeat
IPR001298 Filamin/ABP280 repeat
IPR001841 Zinc finger, RING-type
IPR003649 B-box, C-terminal
IPR013017 NHL repeat, subgroup
IPR014756 Immunoglobulin E-set
IPR017868 Filamin/ABP280 repeat-like
IPR018957 Zinc finger, C3HC4 RING-type

PFAM

PF00643
PF01436
PF13639
PF14634
PF00630
PF00097

PRINTS

PIRSF

SMART

SM00336
SM00557
SM00184
SM00502

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A4IF63