InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BT.68871

Summary

InnateDB Protein

IDBP-680475.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.68871

Protein Name

retinoblastoma-associated protein

Synonyms

P105-RB; PP110; RB11;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000008728

InnateDB Gene

IDBG-629082 (BT.68871)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 226 interaction(s) predicted by orthology.

Predicted by orthology
Total	226 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001047	core promoter binding
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019899	enzyme binding
GO:0019900	kinase binding
GO:0031625	ubiquitin protein ligase binding
GO:0042802	identical protein binding
GO:0051219	phosphoprotein binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006469	negative regulation of protein kinase activity
GO:0007050	cell cycle arrest
GO:0007265	Ras protein signal transduction
GO:0007346	regulation of mitotic cell cycle
GO:0008285	negative regulation of cell proliferation
GO:0030182	neuron differentiation
GO:0031134	sister chromatid biorientation
GO:0031175	neuron projection development
GO:0034088	maintenance of mitotic sister chromatid cohesion
GO:0034349	glial cell apoptotic process
GO:0035914	skeletal muscle cell differentiation
GO:0042551	neuron maturation
GO:0043353	enucleate erythrocyte differentiation
GO:0043550	regulation of lipid kinase activity
GO:0045445	myoblast differentiation
GO:0045651	positive regulation of macrophage differentiation
GO:0045786	negative regulation of cell cycle
GO:0045842	positive regulation of mitotic metaphase/anaphase transition
GO:0045879	negative regulation of smoothened signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048565	digestive tract development
GO:0048667	cell morphogenesis involved in neuron differentiation
GO:0050680	negative regulation of epithelial cell proliferation
GO:0051146	striated muscle cell differentiation
GO:0051301	cell division
GO:0051402	neuron apoptotic process
GO:0051726	regulation of cell cycle
GO:0071459	protein localization to chromosome, centromeric region
GO:0071922	regulation of cohesin localization to chromatin
GO:0071930	negative regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0097284	hepatocyte apoptotic process
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005819	spindle
GO:0016605	PML body
GO:0035189	Rb-E2F complex

Protein Structure and Domains

PDB ID

InterPro

IPR002719 Retinoblastoma-associated protein, B-box
IPR002720 Retinoblastoma-associated protein, A-box
IPR013763 Cyclin-like
IPR015030 Retinoblastoma-associated protein, C-terminal
IPR024599 Retinoblastoma-associated protein, N-terminal

PFAM

PF01857
PF01858
PF08934
PF11934

PRINTS

PIRSF

SMART

SM00385

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite