Version 5.4
Bos taurus Protein: SIRT1
Summary
InnateDB Protein IDBP-680510.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIRT1
Protein Name sirtuin 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000018630
InnateDB Gene IDBG-629119 (SIRT1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 339 interaction(s) predicted by orthology.
Predicted by orthology
Total 339 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002039 p53 binding
GO:0004407 histone deacetylase activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008134 transcription factor binding
GO:0017136 NAD-dependent histone deacetylase activity
GO:0019213 deacetylase activity
GO:0019899 enzyme binding
GO:0033558 protein deacetylase activity
GO:0034979 NAD-dependent protein deacetylase activity
GO:0042393 histone binding
GO:0042802 identical protein binding
GO:0043398 HLH domain binding
GO:0043425 bHLH transcription factor binding
GO:0051019 mitogen-activated protein kinase binding
GO:0070403 NAD+ binding
GO:1990254 keratin filament binding
Biological Process
GO:0000012 single strand break repair
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000183 chromatin silencing at rDNA
GO:0000720 pyrimidine dimer repair by nucleotide-excision repair
GO:0001525 angiogenesis
GO:0001542 ovulation from ovarian follicle
GO:0002821 positive regulation of adaptive immune response
GO:0006325 chromatin organization
GO:0006343 establishment of chromatin silencing
GO:0006344 maintenance of chromatin silencing
GO:0006476 protein deacetylation
GO:0006974 cellular response to DNA damage stimulus
GO:0006979 response to oxidative stress
GO:0007283 spermatogenesis
GO:0007346 regulation of mitotic cell cycle
GO:0008284 positive regulation of cell proliferation
GO:0016239 positive regulation of macroautophagy
GO:0016567 protein ubiquitination
GO:0016575 histone deacetylation
GO:0018394 peptidyl-lysine acetylation
GO:0030308 negative regulation of cell growth
GO:0031937 positive regulation of chromatin silencing
GO:0032007 negative regulation of TOR signaling
GO:0032071 regulation of endodeoxyribonuclease activity
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0033158 regulation of protein import into nucleus, translocation
GO:0034983 peptidyl-lysine deacetylation
GO:0042127 regulation of cell proliferation
GO:0042326 negative regulation of phosphorylation
GO:0042542 response to hydrogen peroxide
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045348 positive regulation of MHC class II biosynthetic process
GO:0045739 positive regulation of DNA repair
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0051097 negative regulation of helicase activity
GO:0051574 positive regulation of histone H3-K9 methylation
GO:0051898 negative regulation of protein kinase B signaling
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0070301 cellular response to hydrogen peroxide
GO:0070932 histone H3 deacetylation
GO:0071356 cellular response to tumor necrosis factor
GO:0071456 cellular response to hypoxia
GO:1901215 negative regulation of neuron death
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:2000480 negative regulation of cAMP-dependent protein kinase activity
GO:2000481 positive regulation of cAMP-dependent protein kinase activity
GO:2000655 negative regulation of cellular response to testosterone stimulus
GO:2000757 negative regulation of peptidyl-lysine acetylation
GO:2000773 negative regulation of cellular senescence
GO:2000774 positive regulation of cellular senescence
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005637 nuclear inner membrane
GO:0005654 nucleoplasm
GO:0005677 chromatin silencing complex
GO:0005719 nuclear euchromatin
GO:0005720 nuclear heterochromatin
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0016605 PML body
GO:0033553 rDNA heterochromatin
GO:0035098 ESC/E(Z) complex
Protein Structure and Domains
PDB ID
InterPro IPR003000 Sirtuin family
IPR026590 Sirtuin family, catalytic core domain
IPR029035 DHS-like NAD/FAD-binding domain
PFAM PF02146
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F1MQB8
UniProt Splice Variant
Entrez Gene 613629
UniGene Bt.97357
RefSeq NP_001179909
HUGO HGNC:14929
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02061808
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca