InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CIAO1

Summary

InnateDB Protein

IDBP-680596.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CIAO1

Protein Name

Probable cytosolic iron-sulfur protein assembly protein CIAO1

Synonyms

WDR39;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000020797

InnateDB Gene

IDBG-629203 (CIAO1)

Protein Structure

UniProt Annotation

Function

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. {ECO:0000255HAMAP-Rule:MF_03037}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.

Predicted by orthology
Total	51 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007059	chromosome segregation
GO:0016226	iron-sulfur cluster assembly

Cellular Component

GO:0071817	MMXD complex
GO:0097361	CIA complex

Protein Structure and Domains

PDB ID

InterPro

IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain

PFAM

PF00400

PRINTS

PIRSF

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q32PJ6

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

540069

UniGene

Bt.51463

RefSeq

NP_001032559

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC108091

GenPept

AAI08092