InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: TRIM13

Summary

InnateDB Protein

IDBP-680626.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM13

Protein Name

tripartite motif-containing protein 13

Synonyms

RFP2;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000010745

InnateDB Gene

IDBG-629232 (TRIM13)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Concentrates and colocalizes with p62/SQSTM1 and ZFYVE1 at the perinuclear endoplasmic reticulum. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0010332	response to gamma radiation
GO:0010942	positive regulation of cell death
GO:0016239	positive regulation of macroautophagy
GO:0016567	protein ubiquitination
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0032897	negative regulation of viral transcription
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087	innate immune response
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051865	protein autoubiquitination
GO:1902187	negative regulation of viral release from host cell

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0097038	perinuclear endoplasmic reticulum

Protein Structure and Domains

PDB ID

InterPro

IPR000315 Zinc finger, B-box
IPR001841 Zinc finger, RING-type
IPR018957 Zinc finger, C3HC4 RING-type

PFAM

PF00643
PF13639
PF14634
PF00097

PRINTS

PIRSF

SMART

SM00336
SM00184

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q32L60

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

535190

UniGene

Bt.5644

RefSeq

NP_001033254

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC109749 DAAA02032918

GenPept

AAI09750