Version 5.4
Bos taurus Protein: WWOX
Summary
InnateDB Protein IDBP-680715.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WWOX
Protein Name WW domain-containing oxidoreductase
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000032547
InnateDB Gene IDBG-629302 (WWOX)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0019899 enzyme binding
Biological Process
GO:0001649 osteoblast differentiation
GO:0008152 metabolic process
GO:0030178 negative regulation of Wnt signaling pathway
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048705 skeletal system morphogenesis
GO:0055114 oxidation-reduction process
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:0097191 extrinsic apoptotic signaling pathway
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005902 microvillus
Protein Structure and Domains
PDB ID
InterPro IPR001202 WW domain
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR013968 Polyketide synthase, KR
PFAM PF00397
PF00106
PF08659
PRINTS PR00080
PR00081
PIRSF PIRSF000126
SMART SM00456
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q0P5N4
UniProt Splice Variant
Entrez Gene 618792
UniGene Bt.88210
RefSeq NP_001071560
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC119823 DAAA02046067 DAAA02046068 DAAA02046069 DAAA02046070 DAAA02046071 DAAA02046072 DAAA02046073 DAAA02046074 DAAA02046075 DAAA02046076 DAAA02046077 DAAA02046078 DAAA02046079 FJ978047
GenPept AAI19824 ADC84386

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca