InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: HAND2

Summary

InnateDB Protein

IDBP-680723.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HAND2

Protein Name

heart and neural crest derivatives expressed 2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000053239

InnateDB Gene

IDBG-629312 (HAND2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003680	AT DNA binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity
GO:0070888	E-box binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001947	heart looping
GO:0001967	suckling behavior
GO:0003007	heart morphogenesis
GO:0003219	cardiac right ventricle formation
GO:0003253	cardiac neural crest cell migration involved in outflow tract morphogenesis
GO:0003266	regulation of secondary heart field cardioblast proliferation
GO:0003278	apoptotic process involved in heart morphogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0007507	heart development
GO:0007512	adult heart development
GO:0010463	mesenchymal cell proliferation
GO:0010667	negative regulation of cardiac muscle cell apoptotic process
GO:0014032	neural crest cell development
GO:0042475	odontogenesis of dentin-containing tooth
GO:0042733	embryonic digit morphogenesis
GO:0043066	negative regulation of apoptotic process
GO:0043392	negative regulation of DNA binding
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043586	tongue development
GO:0045668	negative regulation of osteoblast differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048485	sympathetic nervous system development
GO:0048538	thymus development
GO:0048935	peripheral nervous system neuron development
GO:0060021	palate development
GO:0060485	mesenchyme development
GO:0060536	cartilage morphogenesis
GO:0060982	coronary artery morphogenesis
GO:0061032	visceral serous pericardium development
GO:0061309	cardiac neural crest cell development involved in outflow tract morphogenesis
GO:0061325	cell proliferation involved in outflow tract morphogenesis
GO:0061371	determination of heart left/right asymmetry
GO:2000679	positive regulation of transcription regulatory region DNA binding
GO:2000763	positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process
GO:2000764	positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis