InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: GZMA

Summary

InnateDB Protein

IDBP-680744.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GZMA

Protein Name

Granzyme A

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000039959

InnateDB Gene

IDBG-629338 (GZMA)

Protein Structure

UniProt Annotation

Function

Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}. Cytoplasmic granule {ECO:0000250}. Note=Cytoplasmic granules of cytolytic T- lymphocytes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0008233	peptidase activity
GO:0008236	serine-type peptidase activity
GO:0016787	hydrolase activity

Biological Process

GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0019835	cytolysis
GO:0032078	negative regulation of endodeoxyribonuclease activity
GO:0043065	positive regulation of apoptotic process
GO:0043392	negative regulation of DNA binding
GO:0051354	negative regulation of oxidoreductase activity
GO:0051603	proteolysis involved in cellular protein catabolic process

Cellular Component

GO:0005576

extracellular region

Protein Structure and Domains

PDB ID

InterPro

IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain

PFAM

PF00089

PRINTS

PR00722

PIRSF

SMART

SM00020

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q7YRZ7

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

407178

UniGene

Bt.29672

RefSeq

NP_001001142

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AJ544059

GenPept

CAD66427