Version 5.4
Bos taurus Protein: CIB1
Summary
InnateDB Protein IDBP-680750.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CIB1
Protein Name Calcium and integrin-binding protein 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000028350
InnateDB Gene IDBG-629341 (CIB1)
Protein Structure
UniProt Annotation
Function Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin- stimulated megakaryocytes preventing platelet aggregation. Up- regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Involved in sphingosine kinase SPHK1 translocation to the plasma membrane in a N- myristoylation-dependent manner preventing TNF-alpha-induced apoptosis. Regulates serine/threonine-protein kinase PLK3 activity for proper completion of cell division progression. Plays a role in microtubule (MT) dynamics during neuronal development; disrupts the MT depolymerization activity of STMN2 attenuating NGF-induced neurite outgrowth and the MT reorganization at the edge of lamellipodia. Promotes cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Stimulates calcineurin PPP3R1 activity by mediating its anchoring to the sarcolemma. In ischemia-induced (pathological or adaptive) angiogenesis, stimulates endothelial cell proliferation, migration and microvessel formation by activating the PAK1 and ERK1/ERK2 signaling pathway. Promotes also cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cell membrane {ECO:0000250}. Cell membrane, sarcolemma {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cell projection, filopodium tip {ECO:0000250}. Apical cell membrane {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalized with NBR1 to the perinuclear region. Colocalized with RAC3 in the perinuclear area and at the cell periphery. Colocalized with PAK1 within membrane ruffles during cell spreading upon readhesion to fibronectin. Redistributed to the cytoskeleton upon platelet aggregation. Translocates from the cytosol to the plasma membrane in a calcium-dependent manner. Colocalized with STMN2 to the leading edge of lamellipodia. Colocalizes with PLK3 at the centrosomes in ductal breast carcinoma cells. Colocalized with PPP3R1 at the cell membrane of cardiomyocytes in the hypertrophic heart. Colocalized with STMN2 in the cell body, neurites and growth cones of neurons. Colocalizes with TAS1R2 in apical regions of taste receptor cells (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0044325 ion channel binding
GO:0046872 metal ion binding
Biological Process
GO:0001525 angiogenesis
GO:0001933 negative regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002931 response to ischemia
GO:0006915 apoptotic process
GO:0007026 negative regulation of microtubule depolymerization
GO:0007049 cell cycle
GO:0007113 endomitotic cell cycle
GO:0007155 cell adhesion
GO:0007283 spermatogenesis
GO:0007286 spermatid development
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0010977 negative regulation of neuron projection development
GO:0030154 cell differentiation
GO:0030220 platelet formation
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0031122 cytoplasmic microtubule organization
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0038163 thrombopoietin-mediated signaling pathway
GO:0042127 regulation of cell proliferation
GO:0043066 negative regulation of apoptotic process
GO:0045653 negative regulation of megakaryocyte differentiation
GO:0048554 positive regulation of metalloenzyme activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051301 cell division
GO:0051302 regulation of cell division
GO:0051898 negative regulation of protein kinase B signaling
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071356 cellular response to tumor necrosis factor
GO:0071363 cellular response to growth factor stimulus
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:0090314 positive regulation of protein targeting to membrane
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:1901313 positive regulation of gene expression involved in extracellular matrix organization
GO:1990090 cellular response to nerve growth factor stimulus
GO:2000256 positive regulation of male germ cell proliferation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0030027 lamellipodium
GO:0030426 growth cone
GO:0032433 filopodium tip
GO:0032587 ruffle membrane
GO:0042383 sarcolemma
GO:0042995 cell projection
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0048471 perinuclear region of cytoplasm
GO:0071944 cell periphery
Protein Structure and Domains
PDB ID
InterPro IPR002048 EF-hand domain
PFAM PF00036
PF13202
PF13405
PRINTS
PIRSF
SMART SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q17QE5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 510141
UniGene Bt.677
RefSeq NP_001068901
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC118410
GenPept AAI18411

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca