Version 5.4
Bos taurus Protein: BT.43717
Summary
InnateDB Protein IDBP-680753.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.43717
Protein Name 15-hydroxyprostaglandin dehydrogenase
Synonyms PGDH;
Species Bos taurus
Ensembl Protein ENSBTAP00000027024
InnateDB Gene IDBG-629346 (BT.43717)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004957 prostaglandin E receptor activity
GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity
GO:0016491 oxidoreductase activity
GO:0050662 coenzyme binding
GO:0051287 NAD binding
GO:0070403 NAD+ binding
Biological Process
GO:0006693 prostaglandin metabolic process
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007565 female pregnancy
GO:0007567 parturition
GO:0008152 metabolic process
GO:0045786 negative regulation of cell cycle
GO:0055114 oxidation-reduction process
GO:0097070 ductus arteriosus closure
Cellular Component
GO:0016323 basolateral plasma membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR002424 Alcohol dehydrogenase, insect-type
IPR003560 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
IPR013968 Polyketide synthase, KR
PFAM PF01370
PF00106
PF08659
PRINTS PR00080
PR00081
PR01167
PR01397
PIRSF PIRSF000126
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q309F3
UniProt Splice Variant
Entrez Gene 512259
UniGene Bt.43717
RefSeq NP_001029591
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02021897 DAAA02021898 DQ231564
GenPept ABB18120

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca