InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: DYNC1I1

Summary

InnateDB Protein

IDBP-680754.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DYNC1I1

Protein Name

Cytoplasmic dynein 1 intermediate chain 1

Synonyms

DH IC-1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000020774

InnateDB Gene

IDBG-629340 (DYNC1I1)

Protein Structure

UniProt Annotation

Function

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150- glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000305}. Chromosome, centromere, kinetochore {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	51 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0005515	protein binding
GO:0030507	spectrin binding

Biological Process

GO:0006810	transport
GO:0007018	microtubule-based movement
GO:0008152	metabolic process

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0000922	spindle pole
GO:0005694	chromosome
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005868	cytoplasmic dynein complex
GO:0005874	microtubule
GO:0030286	dynein complex
GO:0031982	vesicle
GO:0036464	cytoplasmic ribonucleoprotein granule

Protein Structure and Domains

PDB ID

InterPro

IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
IPR025956 Cytoplasmic dynein 1 intermediate chain 1/2

PFAM

PF00400
PF11540

PRINTS

PIRSF

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q29RQ3

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

613724

UniGene

Bt.3699

RefSeq

NP_001039981

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC114074

GenPept

AAI14075