Version 5.4
Bos taurus Protein: EDNRA
Summary
InnateDB Protein IDBP-680765.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EDNRA
Protein Name Endothelin-1 receptor
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000018173
InnateDB Gene IDBG-629365 (EDNRA)
Protein Structure
UniProt Annotation
Function Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004962 endothelin receptor activity
GO:0005515 protein binding
Biological Process
GO:0001569 patterning of blood vessels
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007507 heart development
GO:0007585 respiratory gaseous exchange
GO:0008217 regulation of blood pressure
GO:0014032 neural crest cell development
GO:0014824 artery smooth muscle contraction
GO:0015758 glucose transport
GO:0030818 negative regulation of cAMP biosynthetic process
GO:0042310 vasoconstriction
GO:0048484 enteric nervous system development
GO:0060322 head development
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000499 Endothelin receptor family
IPR002175 Endothelin receptor A
IPR017452 GPCR, rhodopsin-like, 7TM
PFAM PF00001
PRINTS PR00237
PR00366
PR00570
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P21450
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281749
UniGene Bt.68265
RefSeq NP_776733
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC133407 BC142309 X57765
GenPept AAI33408 AAI42310 CAA40917

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca