Version 5.4
Bos taurus Protein: CTSB
Summary
InnateDB Protein IDBP-680799.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTSB
Protein Name Cathepsin BCathepsin B light chainCathepsin B heavy chain
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000036650
InnateDB Gene IDBG-629395 (CTSB)
Protein Structure
UniProt Annotation
Function Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
Subcellular Localization Lysosome. Melanosome {ECO:0000250}. Secreted, extracellular space {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0016787 hydrolase activity
GO:0043394 proteoglycan binding
Biological Process
GO:0006508 proteolysis
GO:0030574 collagen catabolic process
GO:0030855 epithelial cell differentiation
GO:0046697 decidualization
GO:0050790 regulation of catalytic activity
GO:0051603 proteolysis involved in cellular protein catabolic process
GO:0097067 cellular response to thyroid hormone stimulus
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0005764 lysosome
GO:0042470 melanosome
GO:0043231 intracellular membrane-bounded organelle
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000668 Peptidase C1A, papain C-terminal
IPR012599 Peptidase C1A, propeptide
PFAM PF00112
PF08127
PRINTS PR00705
PIRSF
SMART SM00645
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P07688
PhosphoSite PhosphoSite-
TrEMBL Q9MZF5
UniProt Splice Variant
Entrez Gene 281105
UniGene Bt.72390
RefSeq NP_776456
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF230197 AH015910 BC102997 L06075 M64620 U16336 U16337 U16338 U16339 U16341 U16342 U16343
GenPept AAA03064 AAA30434 AAA80198 AAF79127 AAI02998 ABJ15785

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca