InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ATP5O

Summary

InnateDB Protein

IDBP-680861.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP5O

Protein Name

ATP synthase subunit O, mitochondrial

Synonyms

OSCP;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000024326

InnateDB Gene

IDBG-629450 (ATP5O)

Protein Structure

UniProt Annotation

Function

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.

Subcellular Localization

Mitochondrion. Mitochondrion inner membrane.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism

Biological Process

GO:0006754	ATP biosynthetic process
GO:0006810	transport
GO:0006811	ion transport
GO:0015986	ATP synthesis coupled proton transport
GO:0015992	proton transport

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005753	mitochondrial proton-transporting ATP synthase complex
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000711 ATPase, OSCP/delta subunit
IPR026015 F1F0 ATP synthase OSCP/delta subunit, N-terminal domain

PFAM

PF00213

PRINTS

PR00125

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P13621

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

281640

UniGene

Bt.49172

RefSeq

NP_776669

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC102204 M18753

GenPept

AAA30676 AAI02205