Version 5.4
Bos taurus Protein: SUPT4H1
Summary
InnateDB Protein IDBP-680909.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SUPT4H1
Protein Name Transcription elongation factor SPT4
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000004389
InnateDB Gene IDBG-629501 (SUPT4H1)
Protein Structure
UniProt Annotation
Function Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0032785 negative regulation of DNA-dependent transcription, elongation
GO:0032786 positive regulation of DNA-templated transcription, elongation
GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0032044 DSIF complex
Protein Structure and Domains
PDB ID
InterPro IPR009287 Transcription initiation Spt4
IPR022800 Spt4/RpoE2 zinc finger
IPR029040 RNA polymerase subunit RPABC4/transcription elongation factor Spt4
PFAM PF06093
PRINTS
PIRSF PIRSF025023
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3SYX6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 616425
UniGene Bt.49115
RefSeq NP_001029964
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103340 BT025461
GenPept AAI03341 ABF57417

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca