Version 5.4
Bos taurus Protein: PELO
Summary
InnateDB Protein IDBP-680912.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PELO
Protein Name Protein pelota homolog
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000004233
InnateDB Gene IDBG-629508 (PELO)
Protein Structure
UniProt Annotation
Function Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential). {ECO:0000250, ECO:0000305}.
Subcellular Localization Nucleus {ECO:0000305}. Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0008283 cell proliferation
GO:0051276 chromosome organization
GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay
GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay
GO:0071025 RNA surveillance
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR004405 Translation release factor pelota
IPR005140 eRF1 domain 1/Pelota-like
IPR005141 eRF1 domain 2
IPR005142 eRF1 domain 3
IPR029064 50S ribosomal protein L30e-like
PFAM PF03463
PF03464
PF03465
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q58DV0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 528728
UniGene Bt.76149
RefSeq NP_001029738
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BT021497 BT025367
GenPept AAX46344 ABF57323

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca