Version 5.4
Bos taurus Protein: ISL1
Summary
InnateDB Protein IDBP-680917.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ISL1
Protein Name islet-1
Synonyms islet-1;
Species Bos taurus
Ensembl Protein ENSBTAP00000001638
InnateDB Gene IDBG-629512 (ISL1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0001105 RNA polymerase II transcription coactivator activity
GO:0001158 enhancer sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043425 bHLH transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001755 neural crest cell migration
GO:0003007 heart morphogenesis
GO:0003139 secondary heart field specification
GO:0003148 outflow tract septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003203 endocardial cushion morphogenesis
GO:0003215 cardiac right ventricle morphogenesis
GO:0003266 regulation of secondary heart field cardioblast proliferation
GO:0006355 regulation of transcription, DNA-templated
GO:0007507 heart development
GO:0008284 positive regulation of cell proliferation
GO:0010468 regulation of gene expression
GO:0010575 positive regulation vascular endothelial growth factor production
GO:0021520 spinal cord motor neuron cell fate specification
GO:0021522 spinal cord motor neuron differentiation
GO:0021524 visceral motor neuron differentiation
GO:0021559 trigeminal nerve development
GO:0021983 pituitary gland development
GO:0030182 neuron differentiation
GO:0031016 pancreas development
GO:0031290 retinal ganglion cell axon guidance
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729 positive regulation of interferon-gamma production
GO:0032730 positive regulation of interleukin-1 alpha production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032735 positive regulation of interleukin-12 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043388 positive regulation of DNA binding
GO:0043524 negative regulation of neuron apoptotic process
GO:0045665 negative regulation of neuron differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048663 neuron fate commitment
GO:0048665 neuron fate specification
GO:0048762 mesenchymal cell differentiation
GO:0048880 sensory system development
GO:0048935 peripheral nervous system neuron development
GO:0048936 peripheral nervous system neuron axonogenesis
GO:0050728 negative regulation of inflammatory response
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060037 pharyngeal system development
GO:0060379 cardiac muscle cell myoblast differentiation
GO:0060384 innervation
GO:0060413 atrial septum morphogenesis
GO:0060913 cardiac cell fate determination
GO:0071657 positive regulation of granulocyte colony-stimulating factor production
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1901258 positive regulation of macrophage colony-stimulating factor production
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001356 Homeobox domain
IPR001781 Zinc finger, LIM-type
IPR009057 Homeodomain-like
PFAM PF00046
PF00412
PRINTS
PIRSF
SMART SM00389
SM00132
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A6H796
UniProt Splice Variant
Entrez Gene 614040
UniGene Bt.28168
RefSeq NP_001092600
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC146163 DAAA02050419
GenPept AAI46164

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca