Version 5.4
Bos taurus Protein: GAB1
Summary
InnateDB Protein IDBP-680934.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GAB1
Protein Name GRB2-associated-binding protein 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000029800
InnateDB Gene IDBG-629529 (GAB1)
Protein Structure
UniProt Annotation
Function Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR) (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.
Predicted by orthology
Total 39 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
Biological Process
GO:0000187 activation of MAPK activity
GO:0006979 response to oxidative stress
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007257 activation of JUN kinase activity
GO:0007507 heart development
GO:0008544 epidermis development
GO:0030334 regulation of cell migration
GO:0043410 positive regulation of MAPK cascade
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0060711 labyrinthine layer development
GO:0070102 interleukin-6-mediated signaling pathway
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001849 Pleckstrin homology domain
PFAM PF00169
PRINTS
PIRSF
SMART SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A6QLU3
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 540085
UniGene Bt.40251
RefSeq NP_001094671
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC148087
GenPept AAI48088

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca