Version 5.4
Bos taurus Protein: NNT
Summary
InnateDB Protein IDBP-680962.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NNT
Protein Name NAD(P) transhydrogenase, mitochondrial
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000015769
InnateDB Gene IDBG-629552 (NNT)
Protein Structure
UniProt Annotation
Function The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.
Subcellular Localization Mitochondrion inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008746 NAD(P)+ transhydrogenase activity
GO:0008750 NAD(P)+ transhydrogenase (AB-specific) activity
GO:0016491 oxidoreductase activity
GO:0050661 NADP binding
Biological Process
GO:0015992 proton transport
GO:0055114 oxidation-reduction process
GO:0072593 reactive oxygen species metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR007698 Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain
IPR007886 Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal
IPR012136 NADP transhydrogenase, beta subunit
IPR026255 NAD(P) transhydrogenase, alpha subunit
IPR029035 DHS-like NAD/FAD-binding domain
PFAM PF01262
PF05222
PF02233
PRINTS
PIRSF PIRSF000204
PIRSF000203
SMART SM01002
SM01003
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P11024
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 280878
UniGene Bt.5120
RefSeq NP_776368
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC114660 J03534 L02543 M22754
GenPept AAA21440 AAA30660 AAA30717 AAI14661

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca